New research indicates that individuals who stop using blockbuster slimming jabs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who halt traditional diet and exercise plans.
Published data in a prominent medical journal shows that while overweight people can lose about a fifth of their total mass while undergoing treatment, the mass returns at an estimated rate of 0.8 kg per month after stopping.
"Users purchasing such drugs need to be cognizant of the potential of fast rebound weight gain when the treatment concludes," cautioned expert Dr. Susan Jebb.
That rate of regain implies a reversion to starting weight within about one and a half years.
Weighing Treatments
The study, which reviewed dozens of trials involving thousands of patients, compared the results of the injectable medications with other pills.
Scientists point out that individuals who lose weight through dieting generally see a less rapid creep back—around 100 grams monthly—after stopping.
The Reason for the Rapid Rebound
Experts suggest the way of the drugs accounts for the accelerated weight return.
These medications imitate a body's own chemical called GLP-1, which controls hunger.
"Long-term administration of GLP-1 levels far above than the body's typical production might result in the body to generate a reduced amount of its own natural hormone, and could reduce sensitivity to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this medication leads to hunger is uncontrolled, making overeating a significant risk."
A Lifelong Condition?
The NHS suggest the jabs for people with obesity-related health risks, alongside recommended lifestyle changes.
Professionals contend that, given the significant potential of weight regain, the therapy is often ongoing.
This view is supported by drug manufacturers, who state that the findings "underscore the persistent nature of obesity," similar to managing diseases like high blood pressure.
User Testimonies
People who have come off the jabs describe a sudden return of cravings.
"It was like a switch that goes on and you become extremely hungry," said a patient.
The struggle is exacerbated if patients have not developed permanent lifestyle or habit modifications during treatment.
Growing Interest
Figures suggest that a significant number of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Adoption is higher among females compared to males.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than public health services.
In conclusion, clinicians caution that while the jabs are effective agents for weight loss, they are not a magic cure and maintained weight loss hinges on combined behavioural changes.
